COVID-19 Vaccine Allergy Case Registry

We have created the COVID-19 Vaccine Allergy Case Registry as a community-wide effort to collect and share case reports on COVID-19 vaccine hypersensitivity reactions. We are collecting potential cases of hypersensitivity reactions, including rashes, swelling, and severe reactions such as anaphylaxis, after a COVID-19 vaccine.

This data collection form is for health care professionals who wish to share reports of possible or confirmed vaccine hypersensitivity.

The case report form will take approximately 10 to 20 minutes to complete. The case report form allows you to save your work and finish at your own pace.

Patient health identifiers such as name or date of birth will not be collected. Only de-identified information and photos will be collected. The information will be kept strictly confidential. Data will be stored on a secure server at Massachusetts General Hospital, a teaching hospital of the Harvard University Medical School. The information is only shared with health care professionals and researchers for managing and improving patient care and expansion of current limited knowledge on COVID-19 vaccine allergy.

This form has been reviewed by the Mass General Brigham (MGB) institutional review board.

Thank you for contributing to this endeavor in collecting reports of COVID-19 vaccine hypersensitivity to better understand the prevalence and symptoms resulting from vaccination. The success of this collaborative effort depends on your active participation, and the accuracy and reliability of the information provided.

In analyses performed from these data, if we use a case you submitted, your name and affiliation (as entered into the dataset) will appear in the “Acknowledgements” section of the manuscript. If your submitted cases comprise a significant proportion of the cases in a study, investigators from Mass General will contact you about possible co-authorship. Co-authorship or joint publications will be based on good faith discussions, and authorship and/or attribution shall reflect generally accepted academic standards. If you would like to discuss a collaborative effort before contributing cases to the registry, please contact us at allergyresearch@MGH.HARVARD.EDU.

Please share the case report survey link with your colleagues and encourage them to report cases of COVID-19 related hypersensitivity reactions. Even if you have submitted the case reports to a journal, we encourage you to enter the cases here as well. This will provide a more precise understanding of the range of hypersensitivity and allergic reactions from COVID-19 vaccination.

Thank you for participating in this community-wide effort.

Kimberly Blumenthal, MD, MSc, Massachusetts General Hospital