Massachusetts General Hospital is recruiting girls and boys with obesity ages 12 - 18 years to study a hormonal treatment for weight loss. Participants have a 50-50 chance of receiving oxytocin, a naturally occurring hormone in the body, or placebo (inactive) nasal spray. The study medication is taken for 12 weeks. The study involves one screening visit to confirm eligibility, and 8 visits over 18 weeks. 3 of these are main visits, 5 are short check ins, and there are 2 additional check-in phone calls with a study clinician.

The main visits include: imaging tests to look at body composition, the brain, and the liver; assessments of how much energy the body burns at rest and after food; blood draws before and after a breakfast meal; nutritional analyses; and survey questionnaires about mood, behaviors, and appetite.

Visits will take place at the MGH main campus in Boston, MA. Participants will receive up to $1700 for completing the study. Local transportation and parking costs will be reimbursed.

Please complete the survey below. If you are eligible to participate in the study we will contact you shortly.

Thank you!

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