Massachusetts General Hospital is recruiting girls and boys with obesity ages 12 - 18 years to study an experimental treatment for weight loss. Participants have a 50-50 chance of receiving the experimental medicine (oxytocin – a naturally occurring hormone in the body) or placebo (inactive) nasal spray. The study medication is taken for 12 weeks. The study involves one screening visit to confirm eligibility, and 8 visits over 18 weeks. 3 of these are main visits, 5 are short safety-check ins, and there are 2 additional check-in phone calls with a study clinician.


The main visits include: imaging tests to look at body composition, the brain, and the liver; assessments of how much energy the body burns at rest and after food; blood draws before and after a breakfast meal; nutritional analyses; and survey questionnaires about mood, behaviors, and appetite.

Visits will take place at the MGH main campus in Boston, MA. Participants will receive up to $1700 for completing the study. Local transportation and parking costs will be reimbursed.

Please complete the survey below. If you are eligible to participate in the study we will contact you shortly.

Thank you!

Loading... Loading...
You have selected an option that triggers this survey to end right now. To save your responses and end the survey, click the button below to do so. If you have selected the wrong option by accident and do not wish to leave the survey, you may click the other button below to continue, which will also remove the value of the option you just selected to allow you to enter it again and continue the survey.
The response has now been removed for the last question for which you selected a value. You may now enter a new response for that question and continue the survey.