Dear Gastroenterology Provider,

Thank you for participating in this survey research study being conducted by Ruma Rajbhandari and Gene Bukhman at Brigham and Women's Hospital to better understand the current state of Crohn's Disease among the poorest billion people.

Inflammatory Bowel Disease (IBD) and Crohn's Disease have historically been regarded as diseases of affluence, with their rapid emergence in Europe and North America in the 20th century, and a more recent rise in developing and newly industrialized countries in Africa, Asia, and South America in the last 25 years. However, limitations in access to diagnosis and treatment in low- and middle-income countries has often led to under recognition of endemic health problems. While there is increasing work on IBD and Crohn's in Upper-Middle Income Countries, there are virtually no published data on the epidemiology and care pathways for these conditions in the countries where the Poorest Billion live.

We are looking to better understand Crohn's in the developing world by surveying gastroenterology specialists in Low and Lower-Middle Income Countries about the state of diagnostic and treatment capacity for Crohn's in their country. Participants who complete the survey will be entered into a drawing for a chance to win an iPad.

All responses will be confidential. Participation is voluntary. Participants have the option to take the survey on-line or through a phone interview. If you are interested in participating, please either: (1) fill out the survey online and click Accept at the bottom of this page, OR (2) email ssmith109@bwh.harvard.edu with your phone number or Skype address and the best dates and times to reach you. We estimate it will take approximately 30 minutes to complete the survey/interview.

If you have any questions or would like to learn more about this study, please contact project manager Samantha Smith at ssmith109@bwh.harvard.edu. If you would like to speak to someone not involved in this research project, you may contact the Partners Human Research Committee at (617) 424-4100. If we do not hear back from you within two weeks, we may contact you again to remind you about the study.

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